There’s quite a few interesting hypes going around the web with regards to Microsoft’s future in terms of UI design. One of the bigger ones is that Windows 8 (yes the desktop OS that comes after Windows 7) would have a theme that would enable a metro like UI (see here).
If you are confused about what this Metro business here’s a good pointer.
The Windows 8 rumors were followed up with a revamp of the Microsoft Site that follows the principles of Metro (see here). What's more is that Office 15 is rumored to have a metro interface as well (see here).
Personally I think metro works. The mantra about typography is beautiful, reduce the clutter, layout is key, “iconify”, and make things easy to access. This has worked very well with the limited real-estate available on the Windows Phone devices. So if it works on a small screen size, why not on a large screen.
One thing I am sure about is that there will be at least a few sites that might copy Microsoft on the principles of metro, if not in current form maybe in other variations, and it would be interesting to see if this would resonate with the designs done for SharePoint.